mAbHits AbvantageTM
The mAbHits AbvantageTM module of the Rational Antibody Discovery platform is an immunoengineering system that manipulates the immune response to control the production of antibodies against defined optimal yet elusive epitopes on a disease-associated protein. AbvantageTM induces a specific and elevated immune response, generating affinity maturation of antibodies against optimal epitopes.
Classical Approaches vs. Rational Antibody Discovery
Missing the Mark
Classical approaches to antibody discovery often led to the majority of antibodies produced missing the optimal epitopes.
AbvantageTM mice
Abvantage mice are transgenic mice designed to produce an immune response that results in majority of the resulting antibodies hitting the desired epitopes.
AbvantageTM mouse
Hummingbird Bioscience’s Rational Antibody Discovery platform conditionally modifies B cells in vivo during immunization to direct optimal antibody responses to epitopes of interest determined with AI-aided algorithms. Our proprietary genetically engineered mice yield robust epitope-focused B cell responses that enable accelerated discovery of high affinity, epitope-specific antibodies.
