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Covid-19 mAb

COVID-19
MONOCLONAL ANTIBODY

Covid-19 mAb (also known as SC31) is a potent SARS-CoV-2 neutralizing antibody for the treatment of COVID-19, developed in collaboration with partners in Singapore and the US.

Pre-clinical data has demonstrated significant therapeutic benefit for Covid-19 mAb in multiple models of COVID-19. After treatment, circulating infectious virus was dramatically lowered and the inflammatory immune responses associated with life-threatening systemic disease were greatly reduced, which together prevented lung damage and significantly improved survival. 

SARS-CoV-2 neutralizing antibodies are promising therapeutics for COVID-19 and offer an important treatment option in the absence of an effective vaccine, and for at-risk patients who may respond poorly to a vaccine.  Emerging data from other antibody programs has been encouraging, however, there remains much to understand about the optimal mechanisms of action and effective treatment strategies. Occurrence of Antibody Dependent Enhancement (ADE) of viral infection, for instance, continues to be a major concern in therapeutics development where sub-optimal antibodies can aid the entry of virus into host cells. This phenomenon has been observed to be a driver of immune dysregulation in severe disease and remains a challenge to be overcome.

Covid-19 mAb binds tightly to a highly conserved viral epitope on the spike protein of all circulating strains of the SARS-CoV-2 virus, and potently blocks viral infection of host cells. Unlike some other therapeutic antibodies in development, Covid-19 mAb also engages with human Fcγ receptors on immune cells to promote natural anti-viral responses without triggering the pro-inflammatory pathways linked to cytokine storms and severe disease. Further, Covid-19 mAb has shown no evidence of ADE.

Covid-19 mAb (also known as SC31) is a potent SARS-CoV-2 neutralizing antibody for the treatment of COVID-19, developed in collaboration with partners in Singapore and the US.

Pre-clinical data has demonstrated significant therapeutic benefit for Covid-19 mAb in multiple models of COVID-19. After treatment, circulating infectious virus was dramatically lowered and the inflammatory immune responses associated with life-threatening systemic disease were greatly reduced, which together prevented lung damage and significantly improved survival. 

SARS-CoV-2 neutralizing antibodies are promising therapeutics for COVID-19 and offer an important treatment option in the absence of an effective vaccine, and for at-risk patients who may respond poorly to a vaccine.  Emerging data from other antibody programs has been encouraging, however, there remains much to understand about the optimal mechanisms of action and effective treatment strategies. Occurrence of Antibody Dependent Enhancement (ADE) of viral infection, for instance, continues to be a major concern in therapeutics development where sub-optimal antibodies can aid the entry of virus into host cells. This phenomenon has been observed to be a driver of immune dysregulation in severe disease and remains a challenge to be overcome.

Covid-19 mAb binds tightly to a highly conserved viral epitope on the spike protein of all circulating strains of the SARS-CoV-2 virus, and potently blocks viral infection of host cells. Unlike some other therapeutic antibodies in development, Covid-19 mAb also engages with human Fcγ receptors on immune cells to promote natural anti-viral responses without triggering the pro-inflammatory pathways linked to cytokine storms and severe disease. Further, Covid-19 mAb has shown no evidence of ADE.

Covid-19 mAb blocks SARS-CoV-2 spike protein from binding hACE2 protein and infecting host cells

Receptor
Binding
Domains

SARS-CoV-2 Spike Protein

Covid-19 mAb has been engineered for drug stability and developability. Robust manufacturing and testing processes have been established that allow Covid-19 mAb to be produced at large scale, with a GMP-validated high-expression Master Cell Bank producing over 4 g/L.

References:
Lv, , Z., et al (2020) Science 369: 1505-1509

Publications

Chan, C. E. Z., Seah, S. G. K., De Hoe Chye, Massey, S., Torres, M., Angeline P.C. Lim, et al. (2020). The Fc-mediated effector functions of a potent SARS-CoV-2 neutralizing antibody, SC31, isolated from an early convalescent COVID-19 patient, are essential for the optimal therapeutic efficacy of the antibody. bioRxiv, 2020.10.26.355107.
http://doi.org/10.1101/2020.10.26.355107

Related News

27 October 2020

Hummingbird Bioscience receives clinical trial authorization to initiate a Phase I/II clinical trial for Covid-19 mAb, an anti-SARS-CoV-2 antibody for the treatment of COVID-19. A pre-print paper is published on bioRxiv.

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JLABS Texas Medical Center
2450 Holcombe Blvd Suite J Houston, TX 77021

Registered Company No:
201505192N
Temasek Lifescience Laboratories
1 Research Link
Singapore 117604
For general enquiries, please contact contact@hummingbirdbio.com

For career enquiries, please contact careers@hummingbirdbio.com
JLABS Texas Medical Center
2450 Holcombe Blvd Suite J
Houston, TX 77021
Temasek Lifescience Laboratories
1 Research Link
Singapore 117604
Registered Company No: 201505192N
For general enquiries, please contact contact@hummingbirdbio.com
For career enquiries, please contact careers@hummingbirdbio.com
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